SQL and Exchange both fall under the category of "does not play well with 
others" in my opinion.  Unless both databases are very small with very few 
concurrent transactions, or the server is part of a really beefy cluster, I'd 
highly recommend against it.  It's just not worth the headache.  Both of them 
are notorious hogs of system resources; both kind of expand to use whatever's 
available.

I'd also advise against it based on "single point of failure" doctrine - your 
life would probably not be fun if both your SQL server and Exchange server were 
dead at the same time.  On SBS, with small d/b's and a limited number of users, 
chances are good you'd be fine - SBS is designed to share system resources that 
way.  That's why the number of possible users is so limited.
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