If you lose only a single Exchange server, then no. You cannot lose a message.

Here is a discussion about shadow redundancy, compared between Exchange 2010 
and 2013.

http://technet.microsoft.com/en-us/library/dd351027(v=exchg.150).aspx

From: [email protected] [mailto:[email protected]] On 
Behalf Of Connolly, Peter
Sent: Tuesday, October 22, 2013 3:23 PM
To: [email protected]
Subject: [Exchange] can Exchange 2010 lose mail through HUB server?

All,

6 CAS/HUB servers, CAS Array, hardware load balanced, 6 mailbox servers in a 
DAG.  We mirror the LUNS for the logs and queue on the CAS/HUB servers.  I was 
asked by a manager if it was possible to lose a piece of mail in our design.  
So for instance if a message reached a HUB server, and the server crashed (say 
a complete loss...) before the message could be sent to a `mailbox server, is 
that message lost irretrievably?  Will the originating  mail server in this 
case receive an NDR?

Thanks in advance,

Peter

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