You can enable admin logging for user mailboxes to make some determination 
about what might be failing. AND, you can test whether a new profile fixes the 
issue (you don’t have to commit to a test profile!).

If exchange is having issues accessing DCs you should be getting some serious 
errors in the Application event log.

From: [email protected] [mailto:[email protected]] On 
Behalf Of Todd Lemmiksoo
Sent: Thursday, September 11, 2014 10:31 PM
To: [email protected]
Subject: [Exchange] Restarting Information Store service

I have a problem with users that have shared mailboxes in Outlook. When the 
user clicks on the shared mailbox in Outlook they the "you do not have 
permissions" error message.
This started after we had to stop AD replication on the domain controllers due 
to corruption in one of our group policies. After we got the gpo fixed we 
restarted replication. This was when the cannot open shared mailboxes started.
My thought is to restart the Information Store Service on the active DAG member.
Any other options other then removing the users Outlook profile and re-adding 
it.


--
T. Todd Lemmiksoo

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