Good from here. As long as your MX lookup on your exchange server looks as 
below they don’t want to talk to you.

Non-authoritative answer:
animikisee.ca   MX preference = 10, mail exchanger = mail.animikisee.ca

mail.animikisee.ca      internet address = 184.70.35.78

From: [email protected] [mailto:[email protected]] On 
Behalf Of Steve Ens
Sent: Tuesday, October 7, 2014 4:12 PM
To: [email protected]
Subject: Re: [Exchange] 421 4.2.1 Unable to connect errors

one of the domains is animikisee.ca<http://animikisee.ca> but I can send to it 
from gmail no problem.  Test the email address 
[email protected]<mailto:[email protected]>


On Tue, Oct 7, 2014 at 3:06 PM, Kennedy, Jim 
<[email protected]<mailto:[email protected]>> wrote:
Toss us a domain so we can try from ours. Go off list if need be.

From: [email protected]<mailto:[email protected]> 
[mailto:[email protected]<mailto:[email protected]>] 
On Behalf Of Steve Ens
Sent: Tuesday, October 7, 2014 4:02 PM
To: [email protected]<mailto:[email protected]>
Subject: Re: [Exchange] 421 4.2.1 Unable to connect errors

Yes, already tried that.  I can do a MX lookup, but cannot telnet to the 
server.    Also getting this in the logs Error Code: 10061, Error Message: No 
connection could be made because the target machine actively refused it
That seems to point to us being blacklisted, but I come up clean on the 
mxtoolbox tests.

On Tue, Oct 7, 2014 at 2:48 PM, Kennedy, Jim 
<[email protected]<mailto:[email protected]>> wrote:
What are the domains? Could be bad bounces from spam to non-existent domains  
Your server can not contact them, so it tried alternates either in dns or per 
the RFC’s (for example A record of domain.com<http://domain.com>) and that 
failed. So it is still trying.

Do an MX lookup from your transport server to verify your DNS is working. Then 
try telnet port 25 from the transport server to that IP to verify connectivity. 
What do you get?

From: [email protected]<mailto:[email protected]> 
[mailto:[email protected]<mailto:[email protected]>] 
On Behalf Of Steve Ens
Sent: Tuesday, October 7, 2014 3:42 PM
To: [email protected]<mailto:[email protected]>
Subject: [Exchange] 421 4.2.1 Unable to connect errors

Odd errors in my mail queue.  Just started appearing yesterday.  Most mail gets 
sent, but from certain domains I get these errors.  "Attempted failover to 
alternate host, but that did not suceed."  Anyone see this before?  Exchange 
2010 on Windows 2008 R2.


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