The Cert on your CAS, is it SHA-1.  There are issues with the 066 update and 
SHA-1 that might cause this.

________________________________
From: [email protected] [[email protected]] on behalf 
of David McSpadden [[email protected]]
Sent: Saturday, November 15, 2014 9:54 AM
To: [email protected]
Subject: [Exchange] Outlook 2010 not working on several machines after patches

I brought my exchange CAS and mailbox server up to date last night and this 
morning about 25 workstations across my WAN can not open Outlook.
It keeps asking for their credentials.   I have removed the profile and readded 
it.
It says it can not communicate with the server?


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