You can have your mailboxes on one server,....and spec it for high availability (ie redundant power, redundant Nic's, etc)but you may only achieve around 99% availabiltiy, unless you look at clustering. Without picking a brand of server you will probably need a quad processor server, with 1.5Gb to 2 Gb of RAM. I would then consider how I want to use Storage Groups,.....and DR requirements. Rule of thumb that I use is for every Storage Group(Raid 5) throw a separate Raid 1 set for the Trans logs. From that you should be able to work out suitable raid controllers. Oh and I generally have a Raid 1 set up for the system.
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