I attempted to do this, but was focused on the exchange server and IIS. 
This morning I did not have to reboot: Last night at 9:00 I installed a
GFI Mailsecurity patch to correctly id MIMAIL virus (was being caught as
corrupt zip file).  This installation involved stopping IIS and all
associated services, Stopping Information store, Stoping GFI services. 
Apply patch.  Restart IIS, Information store, GFI.  The only other thing I
did was a full back up of my Information store earlier in the evening.

Last Friday I rebooted the server twice during the day and had lost all my
outlook clients connectivity.  I eventually disabled GFI Mail essentials
and after another reboot, got connectivity back.  I left GFI Mail
essentials service stoped thinking that I had pinpointed the problem, but
Monday and Tuesday morning I had the issue come up again and ended up
rebooting the servers.  I now have Mail Essentials running again and as I
said this morning I did not have to reboot at least not so far :-).

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