I've had some success in the past using this method.
http://blogs.msdn.com/b/scottos/archive/2007/07/12/rough-and-tough-guide-to-identifying-patterns-in-ese-transaction-log-files.aspx
There may be better tools out there now, but it's certainly pinpointed 
potential culprits about 50% of the time.

Nick

From: Vandael Tim [mailto:[email protected]]
Sent: 28 February 2011 08:53
To: MS-Exchange Admin Issues
Subject: Enormous amount of log files

Hello all,

I've ran into a database problem this morning.
As you can see in the image there are a huge amount of log files generated this 
weekend.
Since the volume is only 30GB it ran full with the associated problem of the 
database being dismounted.
Is there any way to detect what/who generated all this traffic?
To solve the issue, I've moved some log files so the database was mountable 
again.
Now I'm running a backup and turned circular logging on to free up some logs.


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