I have a little different take on the out of office backscatter. Even though it is somewhat annoying I actually count ham points for it when it comes to my blacklisting because spammers don't host auto responders. My take is that ham from people who have morons for email admins is still ham. But to clarify, I do try to block spam generated OoO backscatter, but I try to make sure that it doesn't count against the host's IP karma score. The same is true of sender address verification. Spammers aren't verifying addresses on incoming email.
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