On 2012-02-07 18:36, Antonio Leding wrote:
1) Does any cfg file change require a daemon restart?

Effectively, yes.   Note however that files and databases
accessed by lookup do not.

2) Can Exim be restarted in a graceful fashion such that daemon downtime and 
lack of message processing is minimized?

Send the daemon process a SIGHUP.  Documented in
http://www.exim.org/exim-html-current/doc/html/spec_html/ch05.html
section 3, the "-bd" option.
--
Jeremy


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