On *work* system we are seeing messages like this:

2014-09-24 17:48:59 1XWpkP-0004Oc-Ol Berkeley DB error: PANIC: fatal 
region error detected; run recovery
2014-09-24 17:48:59 1XWpkP-0004Oc-Ol Berkeley DB error: page 1: illegal 
page type or format
2014-09-24 17:48:59 1XWpkP-0004Oc-Ol Berkeley DB error: PANIC: Invalid 
argument
2014-09-24 17:48:59 1XWpkP-0004Oc-Ol Berkeley DB error: 
/var/spool/exim/db/retry: pgin failed for page 1
...

The cure is to shut down exim, delete everyting in /var/spool/exim/db/ls 
then restart exim, but an hour later (while processing apparent spam) it 
started up again. Disc space not running out.

So: Bug in exim or bdb. But possibly triggered by spam?

==John ffitch

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