http://www.cnn.com/2003/HEALTH/parenting/11/03/mercury.vaccines.ap/

New study disputes vaccine, autism link

Critics say mercury in shots led to nervous-system problems

CHICAGO, Illinois (AP) --Government researchers say they found little 
evidence of a link between vaccinations and developmental problems in a 
study of more than 140,000 U.S. children.

The report didn't satisfy vaccine critics, who claimed the study's 
initial results showed a stronger connection but were watered down. 
They also noted that the study's lead author now works for a vaccine 
maker.

The study, published Monday in the December issue of Pediatrics, is one 
of the latest attempts to determine whether older vaccines with the 
mercury-containing preservative thimerosal led to nervous-system 
problems such as autism, as some vocal critics contend.

In one group of children studied, routine vaccines in infancy appeared 
to slightly increase the risk for tics. In another group, a slight 
association was seen with language delays but not tics. A third group 
showed no associations with any disorder.

In all, more than 140,000 children were studied and no link was found 
with any other disorders, including autism, said co-researcher Dr. 
Frank DeStefano of the Centers for Disease Control and Prevention.

Many previous studies of vaccines containing the preservative 
thimerosal also failed to find strong evidence of any link.

The new results are reassuring, DeStefano said, and more definitive 
answers are expected from in-person examinations the CDC is giving some 
of the study participants.

Charges of a cover-up

But Dr. Mark Geier, a geneticist who has worked as a consultant on 
parents' lawsuits against vaccine makers, said the researchers' own 
earlier analysis of the study results found strong links between 
vaccines and such problems -- and that the published results attempt to 
conceal those findings. He claimed the final analysis "is intentional 
fraud."

DeStefano acknowledged that the early results suggested stronger links 
with some disorders, though not autism, but denied that there had been 
pressure or a cover-up. He said the final data reflect a more thorough 
recent analysis.

The study's lead author, former CDC researcher Dr. Thomas Verstraeten, 
now works for vaccine maker GlaxoSmithKline in Belgium, and Geier said 
that connection may have influenced how the research was reported.

Verstraeten, who left the CDC in July 2001, did not respond to an 
e-mail request seeking a response, and company spokeswoman Nancy 
Pekarek said he did not wish to discuss the results. She provided a 
written statement in which Verstraeten indicated that since leaving the 
CDC he has worked only as an adviser as the study was finalized and 
prepared for publication.

The researchers analyzed data from three health maintenance 
organizations on children born between 1992 and 1999 and tracked for 
several years. Information was gathered on several neurodevelopmental 
disorders, including autism, attention deficit disorders, stammering 
and emotional disturbances.

While the researchers were beginning to examine their results, public 
health officials were beginning to publicly address concerns about the 
use of thimerosal in childhood vaccines.

Preservative no longer used

Mercury in high doses has been linked with neurodevelopmental problems. 
Parents and others worried about potentially dangerous overexposure to 
thimerosal because of the increasing number of vaccines recommended in 
childhood.

Vaccine makers have since phased out use of thimerosal as a 
preservative in childhood vaccines used in the United States, though 
trace amounts remain in some vaccines.

It is still used as a preservative elsewhere, especially in developing 
countries, said Dr. Thomas Saari, a member of the American Academy of 
Pediatrics' infections diseases committee and a pediatrics professor at 
the University of Wisconsin in Madison.

Vaccine expert Dr. Neal Halsey of Johns Hopkins University said the 
study shows that if there is any association between older vaccines and 
mild disorders, "it must be relatively small."

"A major health risk should have shown up in a consistent pattern in 
all three of the HMOs," Halsey said.

Still, he said the findings might have been different if the 
researchers had done a separate analysis by gender, since boys are much 
more susceptible to mercury exposure than girls.


Copyright 2003 The Associated Press. All rights reserved. This material 
may not be published, broadcast, rewritten, or redistributed.

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