The Dark Night Project at Brown University has been investigating some common 
psychological issues that can arise with many people who set out on the 
meditation path. Common problems include those who enjoyed that sense of 
enhanced sensual awareness on a retreat but then found the sensory overload 
alarming in everyday life; disorienting experiences of depersonalization; and 
manic emotional states. As the effects can last for some years the 
neuroscientists at Brown University are trying to find out why some people find 
meditation plain sailing while others enter the "dark night".

 (The link is to the second of two transcripts but it deals more usefully with 
the problems that can arise following meditation than the first interview which 
is more background info.)

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