Wow, good work, Glenda! Thanks for all that -
Gloria
At 03:28 PM 3/7/2005, you wrote:
Example 6
A recombinant feline .omega.-interferon preparation (Trade Name: INTERCAT) was administered to a 2-year-old crossbred male cat, which was observed to have neutropenia due to a feline leukemia virus infection.
On the first day of examination, the cat had a weight of 3.9 kg and a body temperature of 40.4.degree. C., and lymphatic swelling was observed. The cat had an appetite and vigor. Blood test results were as follows: PCV 22%, WBC 5,800, neutrophil 696, lymphocyte 4,698, monocyte 116, eosinophil 290, and thrombocyte 200,000. In the virus test, an FeLV antigen was detected and an FIV antibody was not detected.
After 5 days, although appetite and vigor were observed, the body temperature was 39.2.degree. C., and blood test results were as follows: PCV 22%, WBC 5,800, neutrophil 131, lymphocyte 4,963, monocyte 219, eosinophil 483, and thrombocyte 200,000.
The INTERCAT was dissolved in a physiological saline solution and was subcutaneously injected at a dose of 4 MU/day for six days. The dose was 1.03 MU/kg per cat weight. A transfusion (lactate Ringer's solution and glucose) was injected by intravenous drip infusion at a dose of 500 ml/day, and an antibiotic (cephalexin) was intravenously injected at a dose of 100 mg twice a day.
On the second day after the administration of the INTERCAT, the body temperature was 39.5.degree. C., and blood test results were as follows: PCV 24%, WBC 4,200, neutrophil 400, lymphocyte 3,400, monocyte 200, eosinophil 200, and thrombocyte 200,000.
On the fourth day, the body temperature was 38.7.degree. C., and blood test results were as follows: PCV 23%, WBC 5,000, neutrophil 1,150, lymphocyte 3,100, monocyte 450, eosinophil 200, and thrombocyte 200,000. On the seventh day, the body temperature was 38.9.degree. C., and blood test results were as follows: PCV 18%, WBC 6,100, neutrophil 1,769, lymphocyte 3,050, monocyte 1,220, eosinophil 61, and thrombocyte 200,000.
In this example, significant recovery of neutrophils was not observed, and abatement of fever and improved general condition were observed.
Take care, Glenda
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