I just saw this in the FIVCATS group, and thought I should post it here. No date is listed, and it may be old, or have already been posted here. Sorry if it's a repeat of another post. I'm still on no mail for this group, so I haven't seem recent posts. Take care everyone! (scroll down past very long signature to see study)

Jenn
http://ucat.us
http://ucat.us/domesticcatlinks.html
Adopt a cat from UCAT rescue:
http://ucat.us/adopt.html  
Adopt a FIV+ cat:
http://ucat.us/AWrescue/FIV/
http://ucat.us/FIVadopt.html
Adopt a FELV+ cat:
http://ucat.us/FELVadopt.html
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
The VT legislature has created a bill that bans ear cropping on dogs in our state, bill number S. 250, please support it!
They are also considering a bill that will require a license for anyone selling animals in our state.
License fees would cover a staff to do inspections for humane welfare of the animals being sold.
Please support these bills by emailing Judiciary Committee Chairman Richard Sears at [EMAIL PROTECTED]
and the sponsor of this proposal, Senator Ann Cummings, at [EMAIL PROTECTED] and telling them you SUPPORT these proposed bills!
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Therapeutic Effects of Zidovudine on Cats Infected with Retrovirus
*Gómez Nélida Virginia, Gisbert, María Amelia, Jauregui, Luis, Feijoo,
Silvia, Martiarena, Beatriz
*Facultad de Ciencias Veterinarias. Universidad de Buenos Aires
Buenos Aires, AR
[EMAIL PROTECTED]

OBJECTIVES

The main objective of this project was to assess the therapeutic effect of
Zidovudine (AZT) on cats infected with either FIV or FeLV at late but not
terminal stages of the respective diseases.

MATERIALS

The clinical trial was started with 10 FIV-infected cats (group 1), 3
FeLV-infected cats (group 2) and 15 healthy FIV/FeLV negative cats (control
group). The control group was used just for technique's standardization,
i.e., Flow Cytometry. Diagnosis was performed by ELISA, detecting p27
antigen for FeLV or antibodies for FIV, in whole blood samples. A nested
PCR was standarized to confirm FIV status. Treatment with AZT was attempted
at an oral dose of 5 mg/Kg, TID during 5 weeks with resting intervals of 4
weeks. The patient's follow up was done weekly, including clinical check
up, hemogram, plasmatic globulin dosage and evaluation of CD4/CD8 rate by
means of flow cytometry. During therapeutic phase AZT was the only drug
used on study groups.

RESULTS

The FIV (+) study group presented the following clinical signs :
lymphadenopathies 83%, gingivitis 67%, pneumonias 27%, pyodermia 29%
uveitis 21%. The FeLV (+) study group showed spastic pupil syndrome,
immunomediated glomerulonephritis and chronic gastroenteritis.

A significant increase (p<0.05, paired T Test with 5% significance rate) in
the CD4/CD8 ratio was found between the 3rd and 4th weeks post-treatment
onset in treated cats compared to time zero. Most of the patients (80%)
underwent 2 years of treatment showing evident enhancement of physical
condition: increase of bodyweight, recovery from gingivitis, pyodermias and
pneumonias, decrease of lymphadenopathies and lack of opportunistic
infections. The side effects, more often observed, In control and study
groups, were diarrhea, anemia and adynamia. These effects were reversible
and controlled upon treatment interruption.

CONCLUSION

Controlling FIV or FeLV infections could be achieve by means of
anti-retroviral therapies. The use of AZT at 5 mg/Kg TID proved to be
effective and safe. However, a tight follow up on patient's conditions
should be done including hemograms and determination of CD4/CD8 rates.
Speaker Information
(click the speaker's name to view other papers and abstracts submitted by
this speaker)

<http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&Author=2124>Silvia
Feijoo
Fac. de Ciencias Veterinarias. UBA

<http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&Author=2155>María
Amelia Gisbert
Fac. de Ciencias Veterinarias. UBA

<http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&Author=2157>Virginia
Gómez Nélida
Facultad de Ciencias Veterinarias. Universidad de Buenos Aires
Chorroarín 280
Buenos Aires, Buenos Aires 1427 AR

<http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&Author=2198>Luis
Jauregui
Fac. de Ciencias Veterinarias. UBA

<http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&Author=2339>Beatriz
Martiarena
Fac. de Ciencias Veterinarias. UBA

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diseases : Zidovudine for Feline Retrovirus
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Copyright 2006, WSAVA
BEGIN:VCARD
VERSION:2.1
N:O'Guin;Jennifer;D.;Ms.
FN:Jennifer D. O'Guin
NICKNAME:Jenn
ORG:UCAT rescue;operations/field work
TITLE:Cat Rescuer
NOTE:I rescue cats. I run a small personal rescue operation, all on my own, and out of pocket. Donations appreciated at any time! Paypal donations can be sent to [EMAIL PROTECTED] or send donations via check or money order to Jennifer O'Guin, PO Box 1008, Hardwick VT. 05843
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URL;WORK:http://ucat.us/adopt.html
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