I would not drug a cat before flying, especially not without a FULL medical workup (including a heart ultrasound). Cats are just as affected by pressure and altitude changes as humans are, and any drug given will have a much stronger effect in the air. This sometimes can lead to medical issues. It's just not worth it, if she meows the whole trip, so what? Cats are allowed, other passengers can't say too much, I wouldn't think. It's only 3 hours max, I think she would be better off undrugged.
BTW, ACE is a horse tranquilizer, or at least it's the most commonly use tranq in horses, for those of you who have never heard of it. Has been known in male horses to cause a relaxation of the penis from the sheath, that does not reverse, causing permanent penile paralysis. Doesn't sound so bad if you're not breeding the horse if you don't know how horse's penis's work, but a horse penis left out of it's sheath quickly dries out, and more or less, dehydrates to the point of turning rancid (horses usually keep their penis pulled up into a protective sheath, it's similar to a dog, but bigger and looser). The only way to save a horse's life that has had this side effect caused by ACE is to amputate the penis... YES you heard that right, this drug, that the vet gave you for your cat, is known to sometimes cause a horse to need it's penis amputated, or the horse dies. Not something I would EVER give any of my animals, IMO. If you choose to sedate the cat at all, I recommend NO more than 1/2 a tablet of Benadryl, but 1/4 would be even better, as the altitude and pressure will make the drug have a stronger effect than it would on the ground. Phaewryn (was Jenn, changed name) http://ucat.us http://ucat.us/domesticcatlinks.html Adopt a cat from Little Cheetah (UCAT) Cat Rescue: http://ucat.us/adopt.html PLEASE DONATE TO THE TANGLE FUND: Tangle is a cat in Greece that was severely injured when someone wrapped wire around his neck to strangle him, Little Cheetah Cat Rescue is raising funds to bring Tangle to Vermont to find him a good home! http://ucat.us/tangle-fund.html DONATE: We could really use a power saw (for construction), a digital camera (for pictures), and more towels! -- No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.1.392 / Virus Database: 268.5.6/336 - Release Date: 5/10/2006