Thanks, Hebert, that's interesting, and glad to have the info correctly. However, I also wonder why FIV cats have so little problem - seems like HIV causes problems ("Aids") quite frequently, but in my experience, FIV cats rarely have FIV related problems. Any thoughts or info on that?

Thanks,

Gloria




On Aug 12, 2009, at 8:14 AM, hebert ferrarezzi wrote:


Hi  MaryChristine and Gloria,
FIV is in fact a closer relative to HIV than is FeLV. The three belong to the same retrovirus family and subfamily, but FeLV belongs to the Gammaretrovirus group, whereas FIV and HIV belong to the Lentivirus group. The severe outcomes of the disease, however, make feline leukemia more analogous to AIDS in some aspects. The discovery of HIV as the causal agent of human immunodeficiency was due to the previous knowledge that FeLV (not FIV) virus causes a similar syndrome in cats. Moreover, FeLV is a model for the study of cancer. Indeed, most of the papers I have cited here about the use of Protein A came from the research group of the late Robert A. Good, a renamed immunologist and oncologist http://www.robertagoodarchives.com/biography.html

Hebert


From: twelvehousec...@gmail.com
Date: Mon, 10 Aug 2009 11:07:37 -0400
To: felvtalk@felineleukemia.org
Subject: [Felvtalk] Research into FeLV: was Staph Protein A

wow, hebert, thank you for these great posts! (and your english is better
than many who claim to be native speakers.)

i have always been under the impression, tho, that FIV, not FeLV, was
considered by researchers to be more analogous to HIV/AIDS (an early
hypothesis which i believe has been adequately disproven), even tho it appears to those of us who aren't scientists but have done the best reading they can that FeLV is much closer in manner of transmission, manifestation,
and course.

gary, have pedersen or levy done any work with this? they're the two folks, off-hand, that i can think of who have consistently continued actually researching FeLV--susan little, as well, seems to have been fairly on top of
what research is going on..... might they know about any researchers
currently working on this?

i remember when i first got involved with FeLV, from living at a sanctuary, and i was asking why no one was doing safe, minimally invasive research on the three main populations of FeLVs in the countries, at that time Best Friends, us, and Angel Wings (in terms of population size)--i was told then that answering the questions that folks on this list and others were already asking would probably require catching the interest of a drug company, as private or academic researchers wouldn't likely have the funding..... (back to my usual comment about how difficult it is to do research on a population
that is regularly treated by immediate euthanasia.)

i'm not sure how many folks here really realize that a great deal of
research on genetic conditions in cats could not have come about without the
involvement--and fundraising--on the part of breeders, determined to
eradicate killers in their own breeds (HCM in maine coons and bengals
immediately comes to mind.) FeLV owners aren't as identifiable an entity as cattery owners, and while their emotional investment is just as great, i'm not sure how to mobilize "us" to perhaps do the same for this illness.....


--
Spay & Neuter Your Neighbors!
Maybe That'll Make The Difference....

MaryChristine
Special-Needs Coordinator, Purebred Cat Breed Rescue (www.purebredcats.org )
Member, SCAT (Special-Cat Action Team)
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