Thanks Amani... this is very helpful and I will do my best to locate
these references... preferably the full articles if they don't charge
too much for them ( I no longer work in hospitals and don't have access
to full medical databases ( for free)...
VERY interesting about the ebola virus and the eyes.... it does indeed
appear that the virus established a foothold in Yogi's eyes.... BUT...
it was also via the eyes that I was able to introduce antiviral meds
that my Veterinary opthalmologist was using off label..... Of course
the target for these meds was the Herpes Virus....but it too ,is, a
retro Virus and these meds "might" have had some effect on the FeLV
virus as well
had I used them for a longer time ( though I would have had to have sold
my house to do so : )
You can find ALL sorts of aid for these Anti Virals if you are using
them for HIV or Herpes 1 or 2 but they are hard to locate at discount
for Veterinary Use..... I really am VERY concerned at the price of Vet
services as I feel they will ultimately reduce the number of pet
owners..... I was able to easily afford to keep 4 cats on a rather low
Social Worker income back in the 80's but keeping one ill FeLV in 2017
can easily add 400.00 a month to ones expenses.... Many people who
might formerly have adopted multiple cats will now only take in one or
two..... All the more reason for forums like ours as it is up to us to
share our knowledge and experiences to help each other avoid total
reliance on a veterinary system that is not always working to preserve
our FeLV cats lives.....
Hi Bob
I am unable to attach the literature regarding the ability of
Doxycycline to interfere with RNA replication and/or interfere with
viral infection, but here are a few titles to look up on the Internet:
- Antiviral activity of doxycycline against vesicular stomatitis virus
in vitro - FEMS Microbiol Lett. 2015
- Control of small inhibitory RNA levels and RNA interference by
doxycycline induced activation of a minimal RNA polymerase III
promoter - 2006 Nucleic Acids Res. 34
- Inhibitory effect of doxycycline against dengue virus replication in
vitro - October 2013 Archives of Virology 159(4)
- Study of the antiviral activity of some derivatives of tetracycline
and non-steroid anti-inflammatory drugs towards dengue virus - August
2013 Tropical Biomedicine 30(4):1-10 (BY THE WAY - DOXYCYCLINE IS A
TETRACYCLINE)
- A study of the clinical activity of a gel combining monocaprin and
doxycycline: a novel treatment for herpes labialis. (2012) J Oral Path
Med 41:61-67
The following paper was interesting in that it explored the role of
Doxycycline in inhibiting tumour cell proliferation, angiogenesis,
metastasis and migration of cancerous cells (including leukemic cells)
from the bone marrow:
- Doxycycline inhibits leukemic cell migration via inhibition of
matrix metalloproteinases and phosphorylation of focal adhesion kinase
- published Molecular Medicine Reports, September 2015 Vol. 12, Issue
3.
Amani
P.S. - By the way, Bob. The other thing that was featured in that show
last night about the fight against Ebola, is that the same doctor who
contracted it and was declared symptom-free, later began to develop
eye problems and when they examined his eye, they found millions of
the Ebola viruses in the eye. The programme explained that the eye was
an area of reduced immunity in the body, and thus, the virus had found
a breeding ground where it remained, though it had been cleared from
the rest of the body. They therefore began treating the doctor's eye,
and the treatment was ultimately successful. It brought to mind the
problems Yogi had had with his eyes, and I wondered if the answer was
similar - that the virus had had a toe-hold there.
-----Original Message-----
From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf
Of ROBERT CHAPEL
Sent: March-01-17 5:02 PM
To: felvtalk@felineleukemia.org
Cc: felvtalk@felineleukemia.org
Subject: Re: [Felvtalk] Knowing the " whys" of Win/Pred/Doxy
Amani...
If we consider the extended time frame for Doxy and multiple courses
of other ABX it makes a certain "intuitive" sense that a non bacterial
infection is going to require a longer period of time to have whatever
non-specific ( read... not related to bacterial infection
necessarily)...? So little research money appears to be devoted to
FeLV that I don't know that we'll know in the next decade unless the
continuing demands of consumers ( who do NOT want to hear , in this
day and age of " Miracles") that there is _ no hope_ for their much
loved
pets) alter this course.??? I STILL bristle when I think of the closed
minds in the medical and Veterinary community and SO resent that
businessmen( Yes...that is what the vast majority are turning into now
that practices are being forced to consolidate into " Health
Systems").. hold the power of life and death over us AND our pets.??
On the plus side.... with the business model being what it is ( and in
contrast to the lost art of " professionalism")? The CONSUMER is
always right.? Vets will be forced, in the future, to work more
closely with the " customers" wishes as attachment to a given vet will
become less common as time goes on and people will " practice shop "
for the answers they want until such time as Vet services become so
expensive that insurance becomes a " must have " and ultimately go the
way of medicine ( ie...being confined to a slate of approved
practitioners... again....limiting choice)...? But... there are some
years to go before that happens and I feel that there IS a window of
opportunity happening NOW and for the next few? years for people to
have some real influence on how Vets practice....?? I am betting, for
example, that had I had the money to go to a more " well to do "
neighborhood where people are more demanding and better informed I
could have found a vet to cooperate... Here in the "sticks" people
just blindly accept what the vet has to say and they still enjoy the
freedom of calling all the shots.....?? This WILL end over the next
couple of years.? I learned a lot with this first experience and made
mistakes that I WILL NOT make again.
BTW....? Do you have any literature in support of the AntiRNA effects
of Doxy...???? I am SO happy that there are still a couple of things
out there that we still can get our hands on that don't have to pass
muster with script pad businessmen....? STILL I am also not advocating
the the medically ill prepared take it upon themselves to decide that
THEY will decide what is best for their animal... If we are going to
go above and beyond our Vets advice it would best be with very sound
reasoning and an EXCELLENT understanding of what we are doing and
why.?? Anything less and the community of Veterinary practitioners
could easily dismiss our successes as "dumb luck" or ascribe them to "
unknown" factors.....? I think this is particularly important re:
Winstrol/Pred/Doxy?? I'd hate to see people going to their vets asking
for this combination of drugs and really having an inadequate
understanding of why they are asking for beyond the fact that it's
been recommended on our forum...??? For m
yself... I am clear on the Whys of Winstrol and Doxy ( though will be
looking for more lit support on the RNA effects of Doxy) but not clear
on the whys of the Pred.
Sorry for taking up so much space here but I'm having an " attack " of
missing my little guy and am tremulous about being caught in the same
position if I take in another FeLV as I am inclined to do....
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