From what I understand, there are three levels of infection:
 
transient viremia
latent viremia
and persistent viremia
 
Usually, there is a 90 day window from when a cat is exposed to the virus; in that time frame three things may happen:
 
the cat may successfully fight off the infection;
the cat may fight off infection to the extent that there is no virus present in blood or saliva, but the virus may have reached an organ or bone marrow and be sequestered there;
the cat may fail to fight off the infection and the virus will spread throughout the bloodstream and saliva.
 
Cats who are infected and completely fight off the virus will test negative on all the tests and can be considered negative. From what I have read, there is a 25% chance of this occurring.
 
Cats who are infected and partially fight off the virus may give discordant test results--a negative IFA and consistently positive ELISA or PCR. This means that while there is no active infection, the cat can possibly become symptomatic or shed virus and be contagious. The virus may also activate during times of stress and the latent infection could turn into persistent infection. Everything I have read about discordant results says that these cats should be treated as positive.
 
Cats who are persistent viremia should be monitored for symptoms and will test positive on any test, including the confirming IFA. They are definitely positive and have little to no chance of reverting.
 
So, it sounds like Pilgrim has not reached the persistent viremia stage. A second ELISA will tell you whether or not Pilgrim has successfully fought the virus off completely. I would wait a few weeks to a couple of months before retesting and I would perform the ELISA first--if it's negative, the infection was likely transient and Pilgrim is probably fine. If it's positive, then retest on the IFA. If that is still negative, then you should probably treat it as discordant and assume that the cat is POSITIVE because he may be able to give the disease to other cats and may become actively symptomatic down the line. I think his prognosis is generally better, however. If the IFA is positive this time around, then he's positive.
 
In the meantime, the advice to boost his immune system is a good one since it's possible he's still in the process of fighting off the virus--immune boosting medication and supplements may help him to do this. I think a new veterinarian is in order and if you can afford it, a trip to a homeopathic vet might help as well--s/he can recommend immune boosting supplements and dosages for your particular cat.
 
Melissa and the foster FeLV positives in NJ
 
 
 
In a message dated 1/6/2005 2:08:50 P.M. Eastern Standard Time, [EMAIL PROTECTED] writes:
Rhonda,

My first point is just advice based on what *I* would
do.  I've only had one FeLV+ cat for just a couple
months now but have a very supportive, educated vet
and have tried to read as much as I can about the
disease as well as discussing it with her.  Based on
what I know about the tests (pretty much what Lora
wrote about in detail), if I were in your position,
I'd take the IFA negative as the defining answer and
mix the kitties, keeping an eye on them and avoiding
any fights, scratches, etc.  I would then probably ask
for another IFA in 60 days and get ALL the cats that
test (if you can afford to!)

But most importantly, I would get a new vet.  Even
though Pilgrim doesn't appear to be FeLV positive,
this vet doesn't sound very educated an open to
treatment for special needs cats.  If you live in a
large enough town, you should be able to find a more
supportive vet.

Just my opinion,
Jill


       
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