Dear FISers,
We have been working in a couple of new ideas for the list. As Pedro has
advanced you, for this new course we have planned two different kind of
discussions, the thematic regular session (both junior and senior), and
a new modality consisting in short discussions about interesting papers
(we will arrange in the refurbished fis webpages a new platform to
upload the papers). In relation to this, let me introduce you our new
web master, David Sierra. We two will try to develop progressively the
new changes, including the suggestions I have already received (Thanks!).
About the sociotype session, in a few weeks I will have finished the
opening text.
I hope we will have an exciting discussion!
All the best,
Raquel
El 10/09/2013 18:05, Pedro C. Marijuan escribió:
Dear FISers,
We start a new course, hopefully retaking our exciting exchanges and
discussions. Next days Raquel will send all of us a few detailed
proposals. Besides our chaired discussion sessions, we are also trying
to develop a new type of sessions, shorter ones, for instance around
interesting publications --sort of a Journal Club. We have planned a
couple of tentative regular sessions (one around the "sociotype", and
another about "Noumena"... well next days we will send more info.
Herein I am adding below an abstract we have just published about
"eukaryotic intelligence". Maybe we can discuss about it until the
next session starts.
best wishes to all
---Pedro
--------------------------
BioSystems 114 (2013) 8-- 24
*On eukaryotic intelligence: Signaling system's guidance in the
evolution of multicellular organization*
Pedro C. Marijuán?, Raquel del Moral, Jorge Navarro
Bioinformation and Systems Biology Group, Instituto Aragonés de
Ciencias de la Salud (IACS), Zaragoza 50009, Spain
Communication with the environment is an essential characteristic of
the living cell, even more when
considering the origins and evolution of multicellularity. A number of
changes and tinkering inventions
were necessary in the evolutionary transition between prokaryotic and
eukaryotic cells, which finally
made possible the appearance of genuine multicellular organisms. In
the study of this process, however,
the transformations experimented by signaling systems themselves have
been rarely object of analysis,
obscured by other more conspicuous biological traits: incorporation of
mitochondria, segregated
nucleus, introns/exons, flagellum, membrane systems, etc. Herein a
discussion of the main avenues of
change from prokaryotic to eukaryotic signaling systems and a review
of the signaling resources and
strategies underlying multicellularity will be attempted. In the
expansion of prokaryotic signaling systems,
four main systemic resources were incorporated: molecular tools for
detection of solutes, molecular
tools for detection of solvent (Donnan effect), the apparatuses of
cell-cycle control, and the combined
system endocytosis/cytoskeleton. The multiple kinds of enlarged, mixed
pathways that emerged made
possible the eukaryotic revolution in morphological and physiological
complexity. The massive incorporation
of processing resources of electro-molecular nature, derived from the
osmotic tools counteracting
the Donnan effect, made also possible the organization of a
computational tissue with huge information
processing capabilities: the nervous system. In the central nervous
systems of vertebrates, and particularly
in humans, neurons have achieved both the highest level of
molecular-signaling complexity and
the highest degree of information-processing adaptability.
Theoretically, it can be argued that there has
been an accelerated pace of evolutionary change in eukaryotic
signaling systems, beyond the other general
novelties introduced by eukaryotic cells in their handling of DNA
processes. Under signaling system's
guidance, the whole processes of transcription, alternative splicing,
mobile elements, and other elements
of domain recombination have become closely intertwined and have
propelled the differentiation capabilities
of multicellular tissues and morphologies. An amazing variety of
signaling and self-construction
strategies have emerged out from the basic eukaryotic design of
multicellular complexity, in millions and
millions of new species evolved. This design can also be seen
abstractly as a new kind of quasi-universal
problem-solving 'engine' implemented at the biomolecular
scale---providing the fundamentals of eukaryotic
'intelligence'. Analyzing in depth the problem-solving intelligence of
eukaryotic cells would help to
establish an integrative panorama of their information processing
organization, and of their capability to
handle the morphological and physiological complexity associated.
Whether an informational updating
of the venerable "cell theory" is feasible or not, becomes, at the
time being -- right in the middle of the
massive data deluge/revolution from omic disciplines -- a matter to
careful consider.
--
-------------------------------------------------
Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta X
50009 Zaragoza, Spain
Tfno. +34 976 71 3526 (& 6818)
pcmarijuan.i...@aragon.es
http://sites.google.com/site/pedrocmarijuan/
-------------------------------------------------
--
---------------------------------------------------------
Raquel del Moral
Grupo de Bioinformacion / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Avda. San Juan Bosco 13, 50009 Zaragoza
Tfno. +34 976 71 44 76
E-mail. rdelmoral.i...@aragon.es
---------------------------------------------------------
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