Dear FIS Colleagues,

Let me start by announcing the *special session on *_*INFORMATION & SYMMETRY*_, in the Symmetry gathering this Summer in Vienna (18-22 July) The deadline for abstract reception in this session has been enlarged until beginnings of next month. Tentatively, it will be chaired by our colleagues Jerry Chandler and Abir Igamberdiev. A special issue has been planned in cooperation with the journal "Information" too. We will celebrate the near 20th anniversary of the first joint session with FIS on information and symmetry (Washington 1995) and the subsequent special issues (Symmetry & Culture, 1996 and 97). It will be a good occasion to meet again and pass over the views developed in this period. Old FISers and members of this list are invited to attend.

And then about the ongoing discussion--responding to the exciting exchanges by Louis and Plamen. This type of abstract discussion is rarely fertile for biological fundamentals, where structure and function become so intertwined that the concrete mechanisms obliterate the quest for too far-reaching generalizations, but it may be interesting for approaching problems such as "distinctions". Some time ago I tried an approach not so different from Spencer Brown's. It was based on "multidimensional partitions", a development of Karl Javorszky (of this list) for set theory out from classical Euler's partitions (the different ways to decompose additively a natural number). It was very interesting finding a natural limit for the total distinctional between members of given set, finding a curious info dynamics of distinctional gains and losses after addition of just one sign or a few signs in the set, a sort of power law in the total decomposition, etc. (most of this was coming from previous works by Karl--we somehow improved the algorithmic, with a few colleagues here in Zaragoza). Then we tried to apply it to prokaryotic complex receptors (2CS, 3CS) and to the "language of cells"... but we reached our math limits very soon (anyhow, some elementary drafts and publc. were left). I keep thinking that it was a serious approach to cellular "distinctions" that could be escalated upwards. Later on, in a couple of papers in BioSystems (2010, 99, 94-103; and 2013, 114, 8-24) we roughly described prokaryotic and eukaryotic signaling machinery in relation with the intelligent advancement of the life cycle of each cell.

About viruses in evolution, we could listen in Vienna (IS4IS & FIS 2015 Conference) to one of the most advanced thinkers, Guenther Witzany. What Plamen suggests about a virus theory from the viewpoint of viruses is not science fiction. It is astonishing what a few crucial proteins of HIV "know" about hundred molecular components of our lymphocytes. It is as if they had conspired with structurally enslaved pieces of former viruses temporarily joining them to create havoc in the machinery of the cellular host. If just 30% of what Guenther says is right, we have to revise the Symbiotic Theory, the Central Dogma, the RNA (inner) cloud, gene expression, biosemiosis, etc.

Echoing the final debates of the previous session, description should go first. And in bio-informational matters there is still plenty to describe.

Best regards--Pedro

Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta X
50009 Zaragoza, Spain
Tfno. +34 976 71 3526 (& 6818)

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