Hi John
You can connect Flex to databases by proxying through server-side scripts
(.NET, PHP, Java). It's important that all of the queries and connection
scripts are kept server-side, as you don't want someone to be able to
maliciously send SQL queries over-the-wire and delete all of your tables.
Create a web service or REST API and then call it from Flex using the
WebService or HTTPService components.
please have a look on these

http://livedocs.adobe.com/flex/3/html/help.html?content=data_access_2.html

http://cookbooks.adobe.com/post_Simple_MySQL_to_Flex-5561.html

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