PSPad doesn't ask you to remove R/O flag, but inform you, the file has R/O flag and ask you if you want to save your file. If you agree, PSPad remove R/O attribute, save your file and restore attribute back.
Go to Program settings / Program 2 and check option: R/O mode changes file attribute. With this settings you will be able to unlock file manually with lock toolbutton -- <http://forum.pspad.com/read.php?4,63962,63965> PSPad freeware editor http://www.pspad.com
