The problem has been solved!

This key was missing from my registry:

HKCR\CLSID\{B54F3741-5B07-11cf-A4B0-00AA004A55E8}\InprocServer32

Within it, there should be a registry value called (Default) which should carry
a Data value of:

C:\Windows\system32\vbscript.dll

Restoring the registry key from another PC did the trick.
PSPad was not to blame. So noted.

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