I don't know if (all of) you performed a disk check for logical (or even
physical) inconsistencies to eliminate this potential source of the problem.

On MS Windows platforms try:
*chkdsk c: /f*
...or even...
*chkdsk c: /f /r*
..._on every disk partition_ (all computers in a collaboration group if
any) where PSPad editor is installed or where files edited in PSPad are located.
Please, make sure that the drive(s) is actually checked for logical (or
physical) errors because it is sometimes automatically skipped during booting up
like when pressing any key to skip the scheduled operation. In such rare cases
try:
[i]fsutil dirty set c:
chkntfs /C c:[/i]
...from a DOS console run as an administrator for every disk partition like I
wrote above.

I can see you've been suffering from this very annoying random issue for at
least several months now. I don't experience it right now but I remember it has
also happened to me many, many years ago. I don't remember any more what was the
reason and what was the solution, unfortunately. I don't remember what was the
editor (was it PSPad or any other editor back then?) either because I have
exchanged my tools many times over past several years. I just would like to help
you by simple guessing. I expect that running "MemTest86" from a bootable USB or
CD drive wouldn't hurt you either.

Anyway... let us know if this or anything else out there helps any one of you.
Good luck! ;-)

-- 
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PSPad freeware editor http://www.pspad.com

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