what is the most common reason for this in Pspad? 

I don't think this is a pspad problem, I think it's a server problem. But I get
the window saying that there is a File save error every time I try to save to my
server. It just started happening after a server reboot and I'm trying to figure
out why. I am also looking into cPanel forums, but I wanted to ask here as well.
Thank you in advance!

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PSPad freeware editor https://www.pspad.com

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