Hello
There would be some problem with file locking.
After any file change OneDrive lock the file and for the time of synchronization
PSPad can't access it. Maybe PSPad 5 has softer file lock than previous version,
caused by new Delphi version. 

Run program settings / Direct edit button
Change:
DontChangeFileAttribute=1
SafeFileSave=1

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Odpovedet emailem