Update. The problem seems to have been caused by using the updater to move from 5.0.7 to 5.5.1. I went into control panel and completely uninstalled PSPad (there were several instances from upgrading over the years) and then did a fresh install of 5.5.1 and it seems to work fine. The upgrade-in-place process (which is relatively new) may still have some issues.
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