for virus scanning you need something like ClamAV, amavis is wrapper application that can call anti-virus programs AFAIK.
Amavis is a combined spam/virus scanner, it uses external programs for this and is able to use multiple programs also so you can say run sophos
AND clamAV for virus scanning while using spamassassin AND dcc for spam filtering, works very very well in my experience.
I used it both on my personal mail server and the student mail server there at work (along with mimedefang for attachment pruning and a boiler plate).
I would highly recomend it.
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