...the board format does not matter much.
It's the CPU model/generation that matters.
For your practical purposes, those Pico-ITX boards behave just like 
your regular PC with a similar CPU.

ATOM and the Core i3/5/7 machines will be all PCI-e and USB = not an 
ideal platform for DOS. See the Vortex86DX on ICOP boards for 
comparison. Much weaker CPU than an ATOM, but should be strong enough 
for DOS-era software.
https://www.icop.com.tw/product_list/44

Sadly, there's no SoundBlaster support - otherwise the VDX boards are 
perfect for DOS.

Frank


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