Hi Anderson,

Thank you so much for your answer.
I really appreciate it.

All the Best,

Seung-Gul
ᐧ

---
*Seung Gul Kang, M.D., Ph.D. *

*Psychiatrist, Associate Professor*; Department of Psychiatry, Gil Medical
Center, Gachon University, School of Medicine, 21, Namdong-daero 774
beon-gil, Namdong-gu, Incheon, 21565, South Korea
*Research scholar*; Sleep Disorders Clinical Research Program, Department
of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 1
Bowdoin Square, 9th floor, Boston, MA 02114, USA
*Collaboration researcher*; Division of Sleep & Circadian Disorders,
Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave,
Boston MA 02115

2016-09-17 3:26 GMT-04:00 Anderson M. Winkler <wink...@fmrib.ox.ac.uk>:

> Hi Seung-Gul,
>
> Please see below:
>
> On 16 September 2016 at 00:52, Seung Gul Kang <sg.kang...@gmail.com>
> wrote:
>
>> Dear Freesurfer experts,
>>
>> 1. I want to compare the area and/or areapial between two groups in qdec
>> menu.
>> I think that the eTIV or total surface area should be used as a covariate.
>> Which is more appropriate between eTIV and total surface area?
>>
>
> Using and not using a global measurement tell each different things, and a
> suggestion (I'd say a recommendation) is to run both ways, i.e., with and
> without global area as nuisance, and use the results from both when reading
> and interpreting the findings.
>
> Regarding ICV, it has substantial correlation with area and it can be
> included as nuisance in the same model in which global area is included. It
> is not a problem that they are correlated as both go as nuisance in the
> group comparison.
>
>
>
>>
>> 2. Is there any guideline or rule for the smoothing in the thickness,
>> area, and volume comparison?
>> How about the smoothing=5?
>>
>
> There is no specific rule. We have investigated with as little as 10 mm on
> the sphere and the results of the default area processing in FS become
> virtually indistinguishable from the exact method that we proposed in 2012.
> Although we did not investigate 5mm, we did look also into the ic5 and ic3
> resolutions and, particularly for the ic5 (that has vertices about 4 times
> farther from each other compared to the default ic7), 10 mm smoothing is
> fine, suggesting that 5 mm would likewise lead to similar results for the
> ic7. A summary of these findings is in a manuscript that we have just
> uploaded to bioRxiv: http://dx.doi.org/10.1101/074666 (for this
> particular question the SI is probably more important).
>
> All the best,
>
> Anderson
>
>
>
>
>>
>> Thank you.
>>
>> Best,
>> Seung-Gul
>>
>> ---
>> *Seung Gul Kang, M.D., Ph.D. *
>>
>> *Psychiatrist, Associate Professor*; Department of Psychiatry, Gil
>> Medical Center, Gachon University, School of Medicine, 21, Namdong-daero
>> 774 beon-gil, Namdong-gu, Incheon, 21565, South Korea
>> *Research scholar*; Sleep Disorders Clinical Research Program,
>> Department of Psychiatry, Massachusetts General Hospital, Harvard Medical
>> School, 1 Bowdoin Square, 9th floor, Boston, MA 02114, USA
>> *Collaboration researcher*; Division of Sleep & Circadian Disorders,
>> Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave,
>> Boston MA 02115
>> ᐧ
>>
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