Sorry, my question wasn't very clear. I meant to ask what sort of biological 
effect you're hoping to measure using MD.

________________________________
From: freesurfer-boun...@nmr.mgh.harvard.edu 
[freesurfer-boun...@nmr.mgh.harvard.edu] on behalf of Shane Schofield 
[shane.schofi...@yahoo.com]
Sent: Friday, August 11, 2017 6:42 AM
To: Freesurfer support list
Subject: Re: [Freesurfer] Mean diffusivity on cortex?

Hi Dr Yendiki, I am studying a group of people with APOE4 and I want to see 
whether cortical MD increases can be detected relative to non-carriers, and if 
so, is the effect size bigger than changes in cortical thickness.



On Friday, August 11, 2017, 11:19:32 AM GMT+1, Yendiki, Anastasia 
<ayend...@mgh.harvard.edu> wrote:


What effect are you trying to measure with MD on the cortex?

________________________________
From: Shane Schofield [shane.schofi...@yahoo.com]
Sent: Friday, August 11, 2017 3:12 AM
To: Freesurfer Support List; Yendiki, Anastasia
Subject: Re: Mean diffusivity on cortex?

Thanks Dr Yendiki.

I am more interested to compare MD in grey matter regions by putting the MD on 
the surface, and then do a glmfit type of comparisons. Is that OK? Would you 
recommend me to smooth the data after spatial normalisation? I have also used 
the mri_cvs_register as described on the tutorial.


On Friday, August 11, 2017, 7:03:49 AM GMT+1, Shane Schofield 
<shane.schofi...@yahoo.com> wrote:


Hi DTI Experts,

Is it sensible to do comparisons of MD on the cortex surface like a normal 
cortical thickness comparisons between group? If the answer is yes, are there 
recommended on smoothing ?

DT_RECON has been completed in Freesurfer.

Thank you.

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