Appreciate it Dr Bruce. Do you have guidelines for smoothing MD? 
Dr Yendiki, I am trying to investigate whether cortical MD can be a marker of 
neurodegeneration. The idea is that during the early stages of a disease, 
cellular microstructure may breakdown before cortical thinning occurs. This 
results in "less" barriers against diffusion resulting in an increase of MD. 

On Friday, August 11, 2017, 5:49:40 PM GMT+1, Bruce Fischl 
<fis...@nmr.mgh.harvard.edu> wrote:

Hi Shane

you probably don't need cvs as it is more to extend the surface-based 
registration to the entire volume. Here you just need the surface-based 
registration I believe. Use mri_vol2surf to sample the FA onto the surface. 
After that it is identical to a thickness study

cheers
Bruce



On Fri, 11 Aug 2017, Shane Schofield 
wrote:

> Thanks Dr Yendiki. 
> 
> I am more interested to compare MD in grey matter regions by putting the MD 
> on the surface, and then do a glmfit type of comparisons. Is that OK? Would 
> you recommend me
> to smooth the data after spatial normalisation? I have also used the 
> mri_cvs_register as described on the tutorial.
> 
> 
> On Friday, August 11, 2017, 7:03:49 AM GMT+1, Shane Schofield 
> <shane.schofi...@yahoo.com> wrote:
> 
> 
> Hi DTI Experts,
> 
> Is it sensible to do comparisons of MD on the cortex surface like a normal 
> cortical thickness comparisons between group? If the answer is yes, are there 
> recommended on
> smoothing ?
> 
> DT_RECON has been completed in Freesurfer.
> 
> Thank you.
> 
> 
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