Dear freesurfer experts,

I started using qdec for comparing cortical measures in adolescent patients 
with ADHD versus typically developing adolescents and I have a few questions 
concerning the ROI analysis as well as the Desikan-Killiany versus Destrieux 

English is not my native language so please excuse typing errors or wrong 
1)      Is it somehow possible to have the significant clusters mapped onto the 
Destrieux atlas in qdec instead of the Desikan-Killiany one?

2)      I would like to export the mean thickness/surface area from significant 
clusters to SPSS to correlate them with clinical symptoms. I understand you can 
either use means from the stats tables (aparc_thikness_lh.txt etc.) or manually 
draw a ROI and then map the lable back to other subjects. But is there also a 
way to simply export the measures from the significant clusters that show up 
without drawing around them or export measures from the peak vertices?

3)      If I use methods as described in 2), do I have to be concerned about 
‘double dipping’ or ‘circular analysis’?

4)      Does the measure ‘area.pial’ you can select during design creation 
correspond to ‘cortical surface area’ and the measure ‘area’ to ‘WM surface 
area’? Which measure do the aparc_area_lh.txt files that I get when generating 
stats data tables correspond to? I do not see aparc_area.pial.txt files, should 
I be getting them?

5)      After reading a lot about correcting for global brain measures I am 
still confused about the best way to do it. I am quite sure that for the 
volume-based measures it is best to control for ICV/eTIV but for thickness and 
surface area I read different approaches from not controling to using total 
brain volume, global thickness or ICV. Is it safe not to control for anything 
for thickness measures as I do not expect any kind of atrophy in my sample? 
What should my decision be based on?

Sorry, these are many questions – I appreciate any thoughts on these problems, 
thank you so much!

Lea Backhausen, B.Sc.

Research Assistant
Department of Child and Adolescent Psychiatry, Faculty of Medicine of the 
Technische Universität Dresden, Dresden, Germany

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