*Postdoctoral position in the Team “Multimodal Neuroimaging and Lifestyle
in Aging and Alzheimer’s disease” (Dr. Gaël Chételat , UMR-S U1237-PhIND,
Caen, France) ** Duration: 2 years (1 year renewable 1 year).
* Starting date: June 2018
* Research team: Multimodal Neuroimaging and Lifestyle in Aging and
Alzheimer’s disease headed by Dr. Gaël Chételat; www.gael-chetelat.fr;
Research unit: INSERM-UNICAEN-EFS UMR-S U1237-PhIND, GIP Cyceron, Boulevard
Henri Becquerel, BP5229, 14 074 CAEN Cedex, France
* Salary: according to experience

*Job Description: *The aim of the project is to investigate vascular and
white matter lesions across the Alzheimer’s disease (AD) continuum using
two large neuroimaging datasets (IMAP+ and Silver Santé Study). The postdoc
will define the optimal methodologies and implement the corresponding
preprocessing pipelines to extract information related with WM lesions from
multimodal neuroimaging data. He will apply these methods to data acquired
in controls and patients. Then he will investigate the changes in normal
aging and across the AD spectrum, and the relationships between WM lesions
and other neuroimaging alterations as well as cognitive deficits in
patients with subjective cognitive decline (SCD), mild cognitive impairment
(MCI), and Alzheimer’s disease (AD). The postdoctoral researcher will have
access to cross-sectional and longitudinal cognitive and neuroimaging data
including, but not limited to, FLAIR, T1, T2, ASL, resting-state and
task-related fMRI, DTI, FDG-PET, and AV45-PET.

*Requirements for applicants: *PhD Degree in neuroscience, psychology,
engineering, or equivalent, and experience in neuroimaging are essential.
The applicant should notably have a solid background in neuroimaging
analyses related to vascular and white matter lesions. Programming skills
are highly desirable though not necessary (Matlab, R, Python, C++, Perl).
Experiences in the treatment of other imaging modalities (fMRI, PET) and
/or experience in the field of normal and pathological aging will be
appreciated, although not essential.

*The lab:* The Multimodal Neuroimaging and Lifestyle in Aging and
Alzheimer’s disease team, headed by Dr. Gaël Chételat, is organized around
four main areas of interest: i) improving neuroimaging biomarkers for early
Alzheimer’s disease diagnosis; ii) further the understanding of the
physiopathological mechanisms of Alzheimer’s disease with multimodal
imaging, iii) investigating the relationships between lifestyle factors and
brain biomarkers and iv) developing non-pharmacological interventions to
promote mental health and wellbeing in aging population. The team is
currently involved in 2 large projects: Multimodality Imaging of
Early-stage Alzheimer’s disease (IMAP+) and Silver Santé Study, a European
study granted by the European Commission (www.silversantestudy.eu; H2020,
2015-PHC-22) assessing the effects of two 18-month interventions (English
versus meditation training) on behavioral and biological markers of aging
and Alzheimer’s disease. The team is included in the INSERM UNICAEN-EFS
UMR-S U1237-PhIND directed by Pr. Denis Vivien and is based at the Centre
Cyceron (Caen, France), a structure devoted to multimodal imaging. The
structure provides a stimulating work environment as it groups several
research units and several research instruments, such as a cyclotron,

*To apply:* Send a CV, motivation letter and contact details of two
academic referees to Gaël Chételat via silversantest...@cyceron.fr.

*Deadline: 15 May 2018*
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