External Email - Use Caution Hello Dr. Greve,
Please see attached the fsgd and contrast files. I would like to know how to interpret the max value and its directionnality. For example, for this contrast : g2v1_CN_AD_NPIDSEV.area.lh.fwhm10_group-x-var_neg, does the negative sign of the max demonstrate that the surface areas of the cuneus and inferior parietal are smaller for the CN group than the AD group as depression severity (NPIDSEV) increases ?
Thank you very much, Adriana
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g2v1_CN_AD_NPIDSEV.fsgd
Description: Binary data
g2v1_AD_MCI_NPIDSEV.fsgd
Description: Binary data
contrast.mtx
Description: Binary data
I'm having problems following your narrative. Can you send the fsgd
and contrast files?
On 7/4/2022 5:37 PM, Adriana Cannizzaro
wrote:
External Email - Use
Caution
Hello Freesurfers,
We performed a whole-brain analysis using general
linear model analysis with FreeSurfer mri_glmfit for
neuropsychiatric symptoms (i.e: depression, etc) to assess
their effect on brain’s cortical volume, thickness and area
between groups (controls vs mild cognitive impairment, control
vs Alzheimer, Alzheimer vs mild cognitive impairment).The
severity score (level is either 1,2 or 3) of the
neuropsychiatric symptoms was included as fixed factors, while
MRI parameters (cortical volume, thickness and areas) were
regarded as dependent variables.
Thus, these are two sets of results for group_x_var
:
For reference :
CN= Control group
MCI= Mild cognitive impairment group
AD: Alzheimer group
NPIDSEV: Depression severity
Contrast
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ClusterNo
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Max
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VtxMax
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Size(mm^2)
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TalX
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TalY
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TalZ
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CWP
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CWPLow
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CWPHi
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NVtxs
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WghtVtx
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Annot
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Explanation
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g2v1_CN_AD_NPIDSEV.area.lh.fwhm10_group-x-var_neg
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is there a difference between the group
VARiable slopes? contrast 0 0 1 -1. t-test with
Group1>Group2 being positive. Note: this is an
interaction between group and VARiable
|
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1
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-2.0763
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158049
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2847.57
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-19.8
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-63.8
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12.5
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0.0077
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0.0066
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0.0088
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3957
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-5537.87
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cuneus
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2
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-2.4711
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147091
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2469.14
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-35.3
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-51.9
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35
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0.0205
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0.0187
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0.0223
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5579
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-7317.77
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inferiorparietal
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g2v1_AD_MCI_NPIDSEV.volume.rh.fwhm10_group-x-var_pos
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is there a difference between the group
VARiable slopes? contrast 0 0 1 -1. t-test with
Group1>Group2 being positive. Note: this is an
interaction between group and VARiable
|
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1
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2.2852
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91120
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1748.47
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63.7
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-39.7
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-4.3
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0.0054
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0.0045
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0.0063
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3263
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4658.91
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middletemporal
|
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We would like to have more
information on the interpretation of these results.
Specifically, we would like to know how to interpret the sign
of the max coefficient in relation to the difference between
the groups on the severity of depression/NPIDSEV and on the
volume/area/thickness of the region of interest. Our
interpretation for the first result for example was that the
difference between the CN and MCI slopes is negative as
depression severity increases, however this does not indicate
the direction of the slopes regarding the area of the cuneus
or the parietal inferior region. Is this correct?
Thank you very much for your
help,
Adriana Cannizzaro
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