I would suspect an overnight update requiring a reboot. There is a
setting in Windows Update to have it notify you rather than seizing your
computer for several hours.
I once had it essentially kill a remote FTP site we had colocated in
Seattle (I was on Bainbridge Island at the time). After their update,
you could connect using Remote Desktop *one* time. To do it again, I had
to call the on-site people to get them to reboot it. And again, and
again, … until I found which Windows Update to back out.
--Barry
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