Some people have suggested I meditate with the goal of perceiving the pain as being separate from me. Or something like that.
The Duloxetine (Cymbalta) has certainly changed my behavior. I am much more patient, considerate, loving, empathic, etc. Some might think I am more like the ideals of Abrahamic faith traditions which raises the question of whether you can be a better person by using meds. Frank ----------------------------------- Frank Wimberly My memoir: https://www.amazon.com/author/frankwimberly My scientific publications: https://www.researchgate.net/profile/Frank_Wimberly2 Phone (505) 670-9918 On Mon, Mar 11, 2019, 12:08 PM Frank Wimberly <[email protected]> wrote: > Pregabalin reduces neuronal calcium currents by binding to the α2δ > subunit of calcium channels, and this particular mechanism may be > responsible for effects in *neuropathic pain*, anxiety, and other > *pain*syndromes. > The exact mechanism of analgesic effect for *gabapentin* has not been > defined. > > Duloxetine inhibits the reuptake of serotonin and norepinephrine (NE) in > the central nervous system. Duloxetine increases dopamine (DA) specifically > in the prefrontal cortex, where there are few DA reuptake pumps, via the > inhibition of NE reuptake pumps (NET), which is believed to mediate > reuptake of DA and NE.[53] > <https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-53> Duloxetine has > no significant affinity for dopaminergic, cholinergic, histaminergic, > opioid, glutamate, and GABA reuptake transporters, however, and can > therefore be considered to be a selective reuptake inhibitor at the 5-HT > and NE transporters. Duloxetine undergoes extensive metabolism > <https://en.m.wikipedia.org/wiki/Metabolism>, but the major circulating > metabolites do not contribute significantly to the pharmacologic activity. > [54] <https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-54>[55 > <https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-Bymaster_2005-55> > > ----------------------------------- > Frank Wimberly > > My memoir: > https://www.amazon.com/author/frankwimberly > > My scientific publications: > https://www.researchgate.net/profile/Frank_Wimberly2 > > Phone (505) 670-9918 > > On Mon, Mar 11, 2019, 11:57 AM Steven A Smith <[email protected]> wrote: > >> Frank - >> > Perhaps annoying clarification. The word closure has two important >> > meanings. >> > >> > In a topological space a set is closed if it is the complement of an >> > open set. >> > >> > In the more concrete case of Rn, which we're talking about, a set is >> > closed if it contains it's limit points (boundary). >> > >> > The other use of closure is the one Glen(?) mentioned. The sum of two >> > elements in the set is in the set and the same for other operations. >> > >> > Barry, help! >> >> Yet more good elaboration/correction. I think for Nick's benefit, the >> second one is *most* relevant, comes closest to your own original >> common-sense idea of "walking around on a surface without falling off"? >> Cannot 2 be derived from 3 with the right assumptions? >> >> Also, I hope your nerve pain is subsiding... I guess this bodes poorly >> for your tennis game? At least overhead slams and solid serves, unless >> it is your off-hand that is afflicted? >> >> I'm unfamiliar with the pain meds you mentioned (really all outside of >> the basic salisylic acid, acetomenophen, and ibuprofen. I was hoping >> your report of the two med's efficacy would lead to some elaboration on >> the question of change of behaviour without change of brain state? >> Where do these meds act? In the brain tissue itself? On the pinched >> nerve? Somewhere in between? And does that just beg the question over >> into whether the spinal chord and the entire nervous system are >> nominally "part of the brain"? >> >> - Steve >> >> >> >> ============================================================ >> FRIAM Applied Complexity Group listserv >> Meets Fridays 9a-11:30 at cafe at St. John's College >> to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com >> archives back to 2003: http://friam.471366.n2.nabble.com/ >> FRIAM-COMIC <http://friam.471366.n2.nabble.com/FRIAM-COMIC> >> http://friam-comic.blogspot.com/ by Dr. Strangelove >> >
============================================================ FRIAM Applied Complexity Group listserv Meets Fridays 9a-11:30 at cafe at St. John's College to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com archives back to 2003: http://friam.471366.n2.nabble.com/ FRIAM-COMIC http://friam-comic.blogspot.com/ by Dr. Strangelove
