Compare the common HLA alleles by country to the apparent transmission.
On 4/20/20, 4:36 PM, "Friam on behalf of uǝlƃ ☣" <[email protected] on
behalf of [email protected]> wrote:
It's unclear to me whether we'd expect the virus to evolve faster or
slower, depending on where it "originated". It seems to me that if it first
appeared in a species that was dissimilar, then when it finally landed in a
more optimal host type, it would evolve quickly (at least in non-critical
regions) to thrive in that host type. On the other hand, if it lands in an
almost already optimal host type, then it shouldn't evolve much at all. And
only if it's under some sort of pressure to evolve (e.g. the immune system)
would it do so quickly.
What *would* you people who can read all this stuff *expect* to happen?
On 4/20/20 3:57 PM, Marcus Daniels wrote:
> As a ballpark the receptor binding domain is 211 residues, so 20^211,
however only a small part of it seems to be actively evolving. [1] (see Table
1)
>
> https://www.biorxiv.org/content/10.1101/2020.03.10.986398v1
>
> *From: *Friam <[email protected]> on behalf of David Eric Smith
<[email protected]>
> *Reply-To: *The Friday Morning Applied Complexity Coffee Group
<[email protected]>
> *Date: *Monday, April 20, 2020 at 3:49 PM
> *To: *The Friday Morning Applied Complexity Coffee Group
<[email protected]>
> *Subject: *Re: [FRIAM] whackadoodles go mainstream!
>
>
https://www.nature.com/articles/s41591-020-0820-9?fbclid=IwAR1vyx1SqreXoeVgFVKBIayEWGOgZn5IbXmx3-V4nsrWiIlrYvYHQW2TuLA
>
> There is discussion in here about the kind of mosaic it is, and the
nearest identified variants for different parts. I find this interesting as a
question in evolutionary dynamics of either convergence or recombination. The
question of how “hard” an engineering problem it is to find non-local
optimizers for various biding problems if you happen not to have templates in
the same basin of attraction is an interesting question to me in methods of
protein biochemistry. The question of what level of sophistication we
currently imagine is in use around the world is a potentially interesting
question of sophistication versus availability of method, also practical if one
works in threat defenses.
--
☣ uǝlƃ
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