From another source (GenBank SRA data) I see several other mutations, A930T, which is in the HR1. This region in part determines how the virus fuses with a cell. They found one nearby at S943P. Here’s some context:
https://www.nature.com/articles/s41422-020-0305-x I see some other mutations in the RBD (receptor binding domain), but they may not be proliferating. I don’t have the breadth of the GISAID data; they are “selective” (cough) about giving it to non-academics. The V483A mutation I also observed. Marcus From: Friam <[email protected]> on behalf of Roger Critchlow <[email protected]> Reply-To: The Friday Morning Applied Complexity Coffee Group <[email protected]> Date: Tuesday, May 5, 2020 at 1:09 PM To: The Friday Morning Applied Complexity Coffee Group <[email protected]> Subject: Re: [FRIAM] Positively selected mutations Actually, I should wait and read the whole paper before posting on my phone. It's not a new new strain, it's the strain of Covid-19 that we've been dealing with on the east coast, a mutant first noticed in Italy in February, but it's been spreading quite successfully through Europe and North America. -- rec -- On Tue, May 5, 2020 at 2:49 PM Roger Critchlow <[email protected]<mailto:[email protected]>> wrote: I think the implication is that there is a wave of more infectious covid building right now, just when everyone was looking for a chance to catch their breathand regroup. -- rec -- On Tue, May 5, 2020, 11:47 AM uǝlƃ ☣ <[email protected]<mailto:[email protected]>> wrote: Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this talk of a mutating spike imply something similar will be the case 10 years from now with this one? On 5/5/20 3:47 AM, David Eric Smith wrote: > Have you guys seen this one: > > https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1 > > From Tanmoy Bhattacharya et al. Does not look like good news. -- ☣ uǝlƃ .-. .- -. -.. --- -- -..-. -.. --- - ... -..-. .- -. -.. -..-. -.. .- ... .... . ... FRIAM Applied Complexity Group listserv Zoom Fridays 9:30a-12p Mtn GMT-6 bit.ly/virtualfriam<http://bit.ly/virtualfriam> unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com archives: http://friam.471366.n2.nabble.com/ FRIAM-COMIC http://friam-comic.blogspot.com/
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