https://www.nature.com/articles/s41586-022-05563-7
Take your pluripotent human stem cell line, make 25 cell lines with different molecules tagged for fluorescent microscope imaging, run an automated pipeline to grow and gather images, align according to the apical basal axis, express the remainder of the spatial variation of the tagged features in a spherical harmonic basis. Principal component analysis gets 70% of the variance in the first 8 components. So starting with identical cells and growing in as identical conditions as a microsoft fortune could buy, we get to populations of cells where at least 30% of the variation is uncorrelated noise? I'm not sure whether I'm more impressed that the cells imposed that much order or more disappointed that the experimenters couldn't squeeze the population into a tighter cluster. -- rec --
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