I use ClamAV for Unix/Linux systems. It's a free SourceForge project that's kept very current. I use clamav on my Postfix server with amavis to scan all email for viruses and have been _extremely_ impressed with it's performance. It has a program called "freshclam" to maintain your virus signature database file with the lastest information. You'll want to hook up freshclam as a cronjob.
Here's the main page: http://clamav.elektrapro.com/

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