Couldn't find anything on Titan, but here's to new life discovered. 
Implications?--I can't imagine!

Natalia

RELEASE : 10-320
NASA-Funded Research Discovers Life Built With Toxic Chemical
WASHINGTON -- NASA-funded astrobiology research has changed the 
fundamental knowledge about what comprises all known life on Earth.

Researchers conducting tests in the harsh environment of Mono Lake in 
California have discovered the first known microorganism on Earth able 
to thrive and reproduce using the toxic chemical arsenic. The 
microorganism substitutes arsenic for phosphorus in its cell components.

"The definition of life has just expanded," said Ed Weiler, NASA's 
associate administrator for the Science Mission Directorate at the 
agency's Headquarters in Washington. "As we pursue our efforts to seek 
signs of life in the solar system, we have to think more broadly, more 
diversely and consider life as we do not know it."

This finding of an alternative biochemistry makeup will alter biology 
textbooks and expand the scope of the search for life beyond Earth. The 
research is published in this week's edition of Science Express.

Carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur are the six 
basic building blocks of all known forms of life on Earth. Phosphorus is 
part of the chemical backbone of DNA and RNA, the structures that carry 
genetic instructions for life, and is considered an essential element 
for all living cells.

Phosphorus is a central component of the energy-carrying molecule in all 
cells (adenosine triphosphate) and also the phospholipids that form all 
cell membranes. Arsenic, which is chemically similar to phosphorus, is 
poisonous for most life on Earth. Arsenic disrupts metabolic pathways 
because chemically it behaves similarly to phosphate.

"We know that some microbes can breathe arsenic, but what we've found is 
a microbe doing something new -- building parts of itself out of 
arsenic," said Felisa Wolfe-Simon, a NASA astrobiology research fellow 
in residence at the U.S. Geological Survey in Menlo Park, Calif., and 
the research team's lead scientist. "If something here on Earth can do 
something so unexpected, what else can life do that we haven't seen yet?"

The newly discovered microbe, strain GFAJ-1, is a member of a common 
group of bacteria, the Gammaproteobacteria. In the laboratory, the 
researchers successfully grew microbes from the lake on a diet that was 
very lean on phosphorus, but included generous helpings of arsenic. When 
researchers removed the phosphorus and replaced it with arsenic the 
microbes continued to grow. Subsequent analyses indicated that the 
arsenic was being used to produce the building blocks of new GFAJ-1 cells.

The key issue the researchers investigated was when the microbe was 
grown on arsenic did the arsenic actually became incorporated into the 
organisms' vital biochemical machinery, such as DNA, proteins and the 
cell membranes. A variety of sophisticated laboratory techniques were 
used to determine where the arsenic was incorporated.

The team chose to explore Mono Lake because of its unusual chemistry, 
especially its high salinity, high alkalinity, and high levels of 
arsenic. This chemistry is in part a result of Mono Lake's isolation 
from its sources of fresh water for 50 years.

The results of this study will inform ongoing research in many areas, 
including the study of Earth's evolution, organic chemistry, 
biogeochemical cycles, disease mitigation and Earth system research. 
These findings also will open up new frontiers in microbiology and other 
areas of research.

"The idea of alternative biochemistries for life is common in science 
fiction," said Carl Pilcher, director of the NASA Astrobiology Institute 
at the agency's Ames Research Center in Moffett Field, Calif. "Until now 
a life form using arsenic as a building block was only theoretical, but 
now we know such life exists in Mono Lake."

The research team included scientists from the U.S. Geological Survey, 
Arizona State University in Tempe, Ariz., Lawrence Livermore National 
Laboratory in Livermore, Calif., Duquesne University in Pittsburgh and 
the Stanford Synchrotron Radiation Lightsource in Menlo Park.

NASA's Astrobiology Program in Washington contributed funding for the 
research through its Exobiology and Evolutionary Biology program and the 
NASA Astrobiology Institute. NASA's Astrobiology Program supports 
research into the origin, evolution, distribution and future of life on 
Earth.

For more information about the finding and a complete list of 
researchers, visit:

http://astrobiology.nasa.gov

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