Selma,

I'm personally grateful to you for posting out the op-ed in the NYT which I
had overlooked. This reminds me that the full list of visions at
<www.edge.org> will be viewable tomorrow (6 January).

The contribution I'm looking forward to is by J. Craig Venter and is
trailed by Freeman Dyson below. This concerns the genomic era into which we
are now heading. Ultimately, the genomic era will lead, in my view, to the
replacement of our present oil and gas industry and the total
reorganisation of all production technologies in an entirely new and
dispersed global economic system which will have the most profound effects
on society generally and almost every aspect of our daily lives. 

Obviously I don't have access today to what will be published tomorrow but
as Venter won't have much space he's unlikely to describe his work in
detail I will endeavour to describe briefly what one of his most important
objectives will be at his and Hamilton Smith's Institute for Biological
Energy Alternatives. This will be to produce hydrogen from water by means
of specialised bacteria which undoubtedly will be far more efficient than
by any method presently contemplated (electrolysis of water via nuclear or
silicon cell technology). 

His route will start with the smallest known bacterium, Mycoplasma
genitalium, which has about 470 genes, deleting genes from it until he
arrives at the smallest possible living cell (and able to reproduce, of
course). He will then add genes until it can produce hydrogen gas. This may
involve the addition of scores, or even hundreds, of new genes which will
be necessary in order to supervise complex cycles of organic manufacturing
procedures within the cell in order to arrive at hydrogen at the end.

The unravelling of the human genome -- the largest found in nature -- is
trivial when compared with the difficulties that face Venter and Smith in
the coming years. This is going to be one of the most sophisticated
achievements of mankind ever -- and without any doubt the most difficult to
achieve. It may take a couple of years; it will probably take at least a
decade and may take a lifetime -- and a succession of brilliant molecular
scientists to boot. But the thermodynamics are sound (that is, easily
reproduced equipment -- bacteria -- powered by the prodigious amounts of
solar energy). Apart from relatively trivial investments in infrastructure
(e.g. settling tanks and the like), no other thermodynamic/costly
investment and intermediary procedures are required, as would be necessary
with silicon cell technology or the production of hydrogen from nuclear
power. 

The first and most obvious consequence of this is that almost every region
and country in the world with a reasonable amount of daily sunlight will no
longer be dependent on highly concentrated energy resources such as in the
Middle East, or on the large energy corporations which presently store and
transport oil and gas all round the world and which thus have a
considerable degree of monopolistic power. The new genomic technology, by
itself, will also have the most radical devolutionary effects on the
structure of our governments and will, in my opinion, accelerate the
increasing inability of nation-state governments to control their economic
performance by central directives such as setting interest rates (as is now
very apparent in the US!) or regulating industry.  

Over the longer term, when other bacteria and artificial animals will be
able to produce almost whatever we want by way of material goods of any
specification, the new genomic technologies will have even more profound
consequences, and it is these which interest me particularly.

Keith  

At 09:15 04/01/03 -0500, you wrote:
<<<<
This article from NYTimes.com 
has been sent to you by [EMAIL PROTECTED]
Of course I like Gopnik's suggestion.
Selma
>>>>

Today's Visions of the Science of Tomorrow

January 4, 2003

At the end of every year, John Brockman, a literary agent and the publisher
of Edge.org, a Web site devoted to science, poses a question to leading
scientists, writers and futurists. In 2002, he asked respondents to imagine
that they had been nominated as White House science adviser and that
President Bush had sought their answer to "What are the pressing scientific
issues for the nation and the world, and what is your advice on how I can
begin to deal with them?" Here are excerpts of some of the responses. 

Mapping the Planet 

Over the last decade, the human genome project has laid the foundation for
a comprehensive understanding of human biology. The translation of the new
understanding into cures for human diseases will be a slow and difficult
process. 

Meanwhile, a new century has begun. It is time to begin a bold new
initiative in biology: a planetary genome sequencing project to identify
all the segments of the genomes of all the millions of species that live
together on the planet. 

This would require, first, the aggressive development of new technology for
deciphering genes, comparable to the development of computer technology
during the last half century, so that the cost of sequencing genes can
continue to fall as rapidly as the cost of computing. 

The goal would be to complete the sequencing of the biosphere within less
than half a century, at a cost comparable with the cost of the human
genome. This project would bring an enormous increase in understanding of
the ecology of the planet, which could then be translated into practical
measures to sustain and improve the environment while allowing continued
rapid economic development. It could also lead to the stabilization of the
atmosphere and the climate. Let this century be the century of cures for
planetary as well as human diseases. -- Freeman Dyson, retired professor of
physics, Institute for Advanced Study, Princeton, N.J. 

Professor PlayStation 

While American schools are notoriously underserving their students,
American children are rushing home from class to learn how to succeed in
the alternative universes of video games. They spend dozens of hours every
week exploring virtual worlds, each with its own set of rules. Barring a
complete overhaul of our
schools, makers of game systems like Nintendo and PlayStation will continue
to be the most successful institutions when it comes to captivating young
minds. 

South Korea has already figured this out. More than 60 percent of Korean
homes have broadband Internet access -- and online, multiplayer
role-playing games are immensely popular. Recently, the largest Korean
textbook distributor and an independent software designer joined forces to
make such a game in which children study math, science and history. 

Here in the United States, the Army is using video games to reach
teenagers. With a $7 million budget, it is building a series of games to be
made available as a free download over the Web. The first title, "America's
Army," helps players learn about war tactics by requiring them to rush
through shooter missions armed with guns and grenades. 

But where are the games created to teach young Americans civilian skills?
While televisions and slide shows play a large role in classrooms, video
games are still appallingly underused. Let's match the money and effort
spent on "America's Army" to develop freely available games that teach
about math and science, history and citizenship.-- Justin Hall, electronic
entertainment journalist and
creator of the Web site Justin's Links. 

Little Geniuses 

We need more support for the most productive, and most underfinanced,
scientific community in the country. These scientists and educators do more
to provide the basic intellectual infrastructure of the nation than any
other group. Every year they make fundamental discoveries in physics,
biology, mathematics and psychology, as well as ensure that the discoveries
of previous generations of scientists are passed on to future generations.
Yet they typically receive salaries of zero to $15,000 a year, and 16
percent are below the poverty line. Most of the science educators in this
group actually make major financial sacrifices to do their work. They
receive less federal and state support than any other part of the
scientific community -- no grants, no scholarships, no research and
development write-offs. 

These unsung geniuses, are, of course, children under five and the many
women (and a few men) who take care of them. This may seem like a
motherhood issue; well, actually, it is a motherhood issue. But it's sound
science policy too. Give our children what all scientists need -- lunch,
the right toys, a safe place to play, interesting problems to solve and
someone to talk to, and watch them invent a new world.-- Alison Gopnik,
author of "The Scientist in the Crib: What Early Learning Tells Us About
the Mind." 

Think Small 

The United States has been increasing its research efforts in a broad field
called nanotechnology. Nanotechnology -- its name comes from the Greek work
for dwarf - refers to mechanical engineering on a molecular scale.
Technology based on molecular manufacturing will lead to computer systems a
billion times more powerful than what we have today, aerospace vehicles
with 98 percent less structural mass, and medical tools that can repair
tissues, organs and cells at a microscopic level. 

Molecular manufacturing will be based on molecular machine systems able to
manipulate and assemble molecular components to make larger products. If
you look in a conventional factory today, you will see electronic devices
sensing and controlling processes, but the actual work shaping, moving and
assembling parts is done by machines that, quite naturally, use moving
parts to move parts. 

Yet today's research programs are not focused on developing the molecular
machine technologies essential to molecular manufacturing. Researchers
often see any machinery as somehow archaic, left over from the 19th
century. Thus interest in topics like biotechnology and microelectronics
has diverted resources into short-term efforts that are worth doing, but
not at the expense of neglecting the long-term promise of nanotechnology.
-- K. Eric Drexler, founder of the Foresight Institute and author of
"Nanosystems: Molecular Machinery, Manufacturing
and Computation; Unbounding the Future." 

Science Without Secrets 

My advice is to keep science public. Secret knowledge, no matter how
laboriously acquired, is less than science. 

Some knowledge, of course, must remain secret for the security of the
nation. But unless there is a clear security risk, publish all else. Why?
Science belongs to the people: they pay for it; they benefit from it. The
benefits of scientific knowledge accrue far more rapidly when that
knowledge lies open for all to see, to test and to try. 

In my field, quantum computation, openness is beneficial. Quantum mechanics
is famously weird, and one of the consequences of quantum weirdness is that
even a small quantum computer, consisting of a few thousand atoms, has the
potential to break all existing public-key cryptosystems. 

Thus, quantum computers pose a significant threat to the security not only
of classified encoded material, but also of most commercial transactions.
Yet our national security agencies have elected to award grant money for
quantum computing research with the stipulation that the results be
published. 

This is a wise policy. There is no doubt large-scale quantum computers will
pose a risk to security. But they don't how exist, and constructing them
will require the scientific and engineering community to solve wide-ranging
problems of nanofabrication and control. The potential benefits of such
research are a thousand times greater than any drawback from potential
disruption to security. -- Seth Lloyd, a professor of quantum-mechanical
engineering at the Massachusetts Institute of Technology. 

Fending Off the Big One 

As an astrophysicist, I admit that few issues in my trade could be
considered pressing. However, there is one aspect of my work that could
have deadly consequences -- or, more precisely, will have deadly
consequences if it is ignored. Here is where heaven and Earth meet: in the
long-run certainty that people will die from the effects of an asteroid,
large or small, hitting the planet. 

NASA has been discovering and tracking asteroids, but the financing had not
been sufficient to catalog most of them, and no money had gone to study how
an asteroid might be deflected, even though the technology has, in
principle, been available. 

Fortunately, it is rather straightforward to develop a spacecraft that
could reach a 100-meter diameter asteroid and give it a nudge so that it
would miss the earth. For example, scientists have made great strides with
plasma engines -- which are much more effective than traditional chemical
engines and use radio waves to heat their fuel and magnetic fields to
direct a stream of ultrahot ionized gases which could be used as space "tug
boats." 

All we have to do is carry out a test mission in which we demonstrate the
ability to significantly alter an asteroid's orbit. Then when we discover
an asteroid with our name on it, we will be prepared. Plasma engine
advances would also speed up human expansion into space. This initiative
could open the door to populating other worlds while at the same time
making our own world a safer place. -- Piet Hut, astrophysicist, Institute
of Advanced Study, Princeton, N.J. 

Intellectual Globalization 

Both art and science address the most profound issues of the day yet often
face each other across a great divide. A new National Institute for
Humanism would encourage collaborations across the arts, humanities and
sciences in tackling important questions about who and what we are. Call it
the intellectual equivalent of globalization. 

Milan Kundera once wrote that every novel offers some answer to the
question. "What is human existence and wherein does its poetry lie?" I
submit that so does every work of important science. -- Nancy Etcoff,
author and instructor in the department of psychiatry at the Harvard
Medical School. 

Cassandras of the Labs 

Scientists are as much victims of fashion as ordinary mortals are - a fact
illustrated by the rich history of junk science and false alarms of the
last 30 years. Recall a few instances: 

In the mid-1970's, many climatologists warned of an ice age that would
severely diminish agricultural productivity by the year 2000. 

In 1972, the United States banned DDT, only to find out, years later, that
the evidence of the pesticide's harmful effects on human beings is
inconclusive. In the meantime, millions of people -- 1 in 20 African
children, for example -- have died of malaria, as Europe and the United
States remain reluctant to support controlling mosquitoes with DDT. 

And let's not forget the dire warnings about natural resources. In the
1970s, we were told that there would be essentially no oil left by the 1990s. 

Science retains its alarmist streak today. The scuttlebutt among the
scientists I know is that they have a better chance of getting a government
or private grant if they indicate that their research might uncover a
serious threat or problem. Media fascination with bad news is partly to
blame, along with the principled gloominess and nagging of nongovernmental
pressure groups. But government itself has played its natural part. 

The point is not to be cynical about science fads but to know enough to
choose wisely when it comes to supporting pure science, along with research
that can give us beneficial technologies. -- Denis Dutton, Department of
Philosophy, University of Canterbury, New Zealand. 

Really Popular Science 

I believe that if 1 percent of the money now being distributed for science
went to research that was of real interest to taxpayers, science would
become more popular. 

At present, money generally goes to research sought by the scientific
establishment, corporations and government bureaucracies. The
administration of science is neither democratically accountable, nor
carried out in a democratic
spirit. 

My proposal is that 99 percent of the research funds continue to be
allocated in the usual way. But I suggest that 1 percent be spent in a way
that reflects the curiosity of lay people, who pay for all publicly
financed research through taxes. It would be necessary to create a separate
body. One possible name would be the National Discovery Center. 

The center would be governed by a board representing a wide range of
interests, including nongovernmental organizations, schools and voluntary
associations. Individuals could send suggestions in over the Internet.
Local and national organizations could lobby for projects. Potential
subjects for research could be discussed in the news media. 

This new venture would make science more attractive to young people,
stimulate interest in scientific thinking and hypothesis-testing, and help
break down the depressing alienation many people feel from science. --
Rupert Sheldrake, author of "Dogs That Know When Their Owners Are Coming
Home, and Other Unexplained Powers of Animals." 

http://www.nytimes.com/2003/01/04/opinion/04EDGE.html?ex=1042689722&ei=1&en=
fc2bfcb3afb63023
>>>>


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Keith Hudson, General Editor, Handlo Music, http://www.handlo.com
6 Upper Camden Place, Bath BA1 5HX, England
Tel: +44 1225 312622;  Fax: +44 1225 447727; mailto:[EMAIL PROTECTED]
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