Galaxy supports compressed files like gz  by default.
Keep in mind that large files like yours are not guaranteed to upload
properly, please use other techniques to get your data in galaxy.
For example with FTP:
Hope that helps,
 .gz/.gzip, .bz/.bzip, .bz2/.bzip2, zip
> Hi all,
> My colleague tried to upload via filesystem path a file with an
> approximate size of 2GB. It was a compressed file (filename.fq.gz). No
> error was reported, so I thought everything went fine, but when he
> tried running a tool, the uploaded file did not show in the input
> dropdown. But when he tried again, this time using an uncompressed
> file, every thing worked well. Now to my question: by default, can
> Galaxy accept and use compressed files? Or do I have to change
> something in its configuration just to do so?
> Thanks for the help!
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