Without details about your incoming data rate and size, it's very difficult to 
answer this question. I suggest taking some of your data, running it on our 
public server (usegalaxy.org), and seeing how long it takes. RNA-seq tools 
(Tophat, Cufflinks, etc.) use 4 cores for a job, so you can estimate how many 
cores you might need (as well as estimate disk space).

You might also look at using Galaxy on the cloud as well: 
http://wiki.galaxyproject.org/CloudMan

Good luck,
J.


On Nov 14, 2013, at 7:07 PM, Andrew Norman <anorma...@gmail.com> wrote:

> Hi all
> 
> I'd like to set up a local installation of Galaxy on a dedicated linux 
> machine. I've taken a look at the Galaxy "appliance", but since I'm the only 
> one in my lab who will be using it, it's outside my price range.
> 
> I'm going to be doing RNA seq read mapping and differential expression 
> analysis. Can anyone recommend some minimum specs for the machine? I 
> understand that more memory/cores will enable faster processing, but I'm 
> willing to wait overnight for results to save some cash. Any advice you have 
> about this will be helpful!
> 
> Thanks,
> Andy
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