Hi all,

We were tracking the galaxy master branch on our local server and are looking 
to migrate to v16.01.
The galaxy processes are managed bij supervisor as shown here ( 
https://wiki.galaxyproject.org/Admin/Config/Performance/Scaling).
After updating all dependencies in our venv we tried to restart the server but 
got the following issue:

Loading paste environment: config:/home/galaxy/galaxy-dist/config/galaxy.ini
Traceback (most recent call last):
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/paste/deploy/loadwsgi.py",
 line 247, in loadapp
    return loadobj(APP, uri, name=name, **kw)
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/paste/deploy/loadwsgi.py",
 line 271, in loadobj
    global_conf=global_conf)
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/paste/deploy/loadwsgi.py",
 line 296, in loadcontext
    global_conf=global_conf)
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/paste/deploy/loadwsgi.py",
 line 320, in _loadconfig
    return loader.get_context(object_type, name, global_conf)
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/paste/deploy/loadwsgi.py",
 line 458, in get_context
    section)
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/paste/deploy/loadwsgi.py",
 line 517, in _context_from_explicit
    value = import_string(found_expr)
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/paste/deploy/loadwsgi.py",
 line 22, in import_string
    return pkg_resources.EntryPoint.parse("x=" + s).load(False)
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/pkg_resources/__init__.py",
 line 2380, in load
    return self.resolve()
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/pkg_resources/__init__.py",
 line 2386, in resolve
    module = __import__(self.module_name, fromlist=['__name__'], level=0)
  File "lib/galaxy/web/buildapp.py", line 5, in <module>
    from galaxy.webapps.galaxy.buildapp import app_factory
  File "lib/galaxy/webapps/galaxy/buildapp.py", line 15, in <module>
    import galaxy.app
  File "lib/galaxy/app.py", line 9, in <module>
    import galaxy.queues
  File "lib/galaxy/queues.py", line 9, in <module>
    from kombu import Exchange, Queue, Connection
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/kombu/__init__.py", 
line 67, in __getattr__
    module = __import__(object_origins[name], None, None, [name])
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/kombu/entity.py", 
line 10, in <module>
    from .abstract import MaybeChannelBound, Object
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/kombu/abstract.py", 
line 12, in <module>
    from .connection import maybe_channel
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/kombu/connection.py",
 line 19, in <module>
    from kombu import exceptions
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/kombu/exceptions.py",
 line 12, in <module>
    from amqp import ChannelError, ConnectionError, ResourceError
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/amqp/__init__.py", 
line 34, in <module>
    from .connection import Connection      # noqa
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/amqp/connection.py",
 line 40, in <module>
    from .transport import create_transport
  File 
"/home/galaxy/galaxy-dist/.venv/lib/python2.7/site-packages/amqp/transport.py", 
line 21, in <module>
    import ssl
  File "/Shared/Software/Cellar/python/2.7.11/lib/python2.7/ssl.py", line 97, 
in <module>
    import _ssl             # if we can't import it, let the error propagate
ImportError: /home/galaxy/galaxy-dist/.venv/lib/python2.7/lib-dynload/_ssl.so: 
undefined symbol: SSL_CTX_set_alpn_protos

So far we have tried:
- rebuilding the venv
- reinstalling python

Funny thing is, when we start the configuration with the “run.sh” script 
instead of through supervisor everything seems to work just fine.

We’re at a loss, please help!
Thanks!
Matthias

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