Hi Nate,

Thanks for the quick response, it gave me the lightbulb I needed.  I did the 
following:

On the cluster side, I custom installed python libraries based on the 
instructions in “Framework dependencies.”  This was placed in the Galaxy 
directory, but there would’ve been access to OS specific libraries.  Then, I 
created a vm-specific directory, and also installed libraries there via 
virtualenv.  In job_conf, I added a line to force use of the Galaxy directory 
venv.  Before starting Galaxy with the –no-create-env and –skip-wheels flags, I 
set GALAXY_VIRTUAL_ENV explicitly to look in the vm-specific venv directory 
(export GALAXY_VIRTUAL_ENV=”/galaxy/venv” && sh run.sh).  This did the trick.  
A job was successfully returned from the cluster and metadata properly set.  My 
only question would be, are any of these steps not necessary?

Thanks for your help!

From: Nate Coraor <n...@bx.psu.edu>
Date: Monday, January 29, 2018 at 7:33 AM
To: John Letaw <le...@ohsu.edu>
Cc: galaxy-dev <galaxy-dev@lists.galaxyproject.org>
Subject: Re: [galaxy-dev] Cluster Install Path Errors

Hi John,

Can you verify that your virtualenv created on the cluster is the one being 
used by jobs? It should be possible to view using a test job's script file, the 
path to which is logged at run time.

Thanks,
--nate

On Mon, Jan 29, 2018 at 1:00 AM, John Letaw 
<le...@ohsu.edu<mailto:le...@ohsu.edu>> wrote:
Hi Nate,

I tried to get this to work, but it is not getting rid of the error.  I was 
able to symlink the platform dependent lib-dynload libraries to a recognized 
directory, which removed the error telling me _hashlib was not found.  Now, I’m 
just left with:

galaxy.jobs.output_checker DEBUG 2018-01-28 21:50:36,883 Tool produced standard 
error failing job - [Could not find platform dependent libraries <exec_prefix>
Consider setting $PYTHONHOME to <prefix>[:<exec_prefix>]
]

Maybe, as Cao suggested, I should just be installing a common version in the 
shared directory between the two filesystems.  The job is correctly being 
scheduled and completes, metadata is just not written.  I’m certainly open to 
any additional ideas.

Thanks,
John

From: Nate Coraor <n...@bx.psu.edu<mailto:n...@bx.psu.edu>>
Date: Thursday, January 18, 2018 at 1:12 PM
To: Cao Tang <charlietan...@gmail.com<mailto:charlietan...@gmail.com>>
Cc: John Letaw <le...@ohsu.edu<mailto:le...@ohsu.edu>>, galaxy-dev 
<galaxy-dev@lists.galaxyproject.org<mailto:galaxy-dev@lists.galaxyproject.org>>
Subject: Re: [galaxy-dev] Cluster Install Path Errors

I think this error most commonly occurs when a virtualenv is used with a 
different python than the one it was created with. Is the cluster also running 
Ubuntu 14.04? If not, you can create a separate virtualenv for running tools 
using the instructions at:

https://docs.galaxyproject.org/en/master/admin/framework_dependencies.html#managing-dependencies-manually

Once created, your tools can use it by setting `<param 
id="GALAXY_VIRTUAL_ENV">/path/to/venv</param>` on the destination in 
job_conf.xml

--nate

On Thu, Jan 18, 2018 at 1:50 PM, Cao Tang 
<charlietan...@gmail.com<mailto:charlietan...@gmail.com>> wrote:
You can try to install:

https://pypi.python.org/pypi/hashlib

On Thu, Jan 18, 2018 at 1:22 PM, John Letaw 
<le...@ohsu.edu<mailto:le...@ohsu.edu>> wrote:
Thanks for the response Peter.  I currently have this instance installed on a 
lustre fs, that is visible on an Ubuntu 14.04 vm.  So, there very well may be 
mismatches between directories on the VM, and those on the lustre cluster.  
This would mean the python installation on the VM needs to exactly match that 
which is on the cluster?  What else will need to match to ensure success?

Thanks,
John

On 1/18/18, 1:50 AM, "Peter Cock" 
<p.j.a.c...@googlemail.com<mailto:p.j.a.c...@googlemail.com>> wrote:

    I *think* this is a problem with your copy of Python 2.7 and a
    standard library (hashlib) normally present. Do you know how this
    Python was installed? If it was compiled from source, then it may have
    been missing a few dependencies, and thus you have ended up with
    missing a few normally present Python modules.

    Peter

    On Wed, Jan 17, 2018 at 11:15 PM, John Letaw 
<le...@ohsu.edu<mailto:le...@ohsu.edu>> wrote:
    > Hi all,
    >
    >
    >
    > I have been trying to finish up a production cluster Galaxy installation,
    > and am having trouble with the below error.  In the past, when seeing
    > something along these lines, I usually can adjust environmental variables
    > either in startup scripts, or by including a script for Galaxy to source
    > before it sends out a job.  I have tried all of these different methods, 
but
    > I can’t seem to get rid of this error message in any tool invocation.  I
    > currently have “embed_metadata_in_job” set to False in my job_conf.xml 
file.
    > This removes a “No module named galaxy_ext.metadata.set_metadata” error, 
but
    > this hashlib error remains.  If I could understand a little more about the
    > steps that are taken when sending out a job, perhaps I could better 
diagnose
    > this?
    >
    >
    >
    > “””
    >
    > Could not find platform dependent libraries
    >
    > Consider setting $PYTHONHOME to [:]
    >
    > Traceback (most recent call last):
    >
    >   File "~/galaxydev/galaxy/tools/data_source/upload.py", line 14, in
    >
    >     import tempfile
    >
    >   File "/usr/lib64/python2.7/tempfile.py", line 35, in
    >
    >     from random import Random as _Random
    >
    >  File "/usr/lib64/python2.7/random.py", line 49, in
    >
    >     import hashlib as _hashlib
    >
    >   File "/usr/lib64/python2.7/hashlib.py", line 116, in
    >
    >     import _hashlib
    >
    > ImportError: No module named _hashlib
    >
    > “””
    >
    >
    >
    > Thanks,
    >
    > John
    >
    >
    > ___________________________________________________________
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