https://gcc.gnu.org/bugzilla/show_bug.cgi?id=66599
--- Comment #2 from Romain Dolbeau <romain.gcc at dolbeau dot name> --- Do you mean "Q" in this case, or always when using ld4/st4 (and probably quite a few others)? If I pre-compute a pointer with src+16, I still get the error (I'm guessing an optimization is propagating the pre-computation down to the ASM statement).