Jennifer,

We want to first thank you for your quick response to our previous questions 
and the valuable information that you provided us.

We are trying to complete our analysis on a set of Illumina and 454 data and 
are using Blat and Bowtie to map our reads.  However, there is little 
documentation on the pslCDNa filter and the pslReps filter, which are used on 
the blat mapped files.  Do you have any specifics on these two filters and what 
exactly they are used for (advantages/disadvantages of one over the other)?

We also wanted to ask you about whether you are aware of any packages that 
support the BLAT format for rna-Seq experiments. Specifically we have been 
using other programs such as Genominator and HTSeq which exploit the 
'ShortRead' package in R to obtain the counts of exons and genes.  However, 
these do not seem to support the BLAT format and are looking for alternatives 
as BLAT works much better for mapping 454 data.

Thanks,
David Drewry



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